反应详情

To a solution of 4-hydroxy-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine (5.8 g; 37.4 mmoles) in benzene (60 cc) and 95% ethanol (30 cc) is added dropwise a mixture of phenyl isothiocyanate (5.05 g; 37.4 mmoles) in benzene (20 cc). After stirring during 2.5 hours at room temperature, the resulting precipitate is filtered off, washed with ether and dried in vacuo (M.p. = 168° C; yield: 79%).

1. filtrationthe resulting precipitate is filtered off
2. washwashed with ether
3. customdried in vacuo (M.p. = 168° C; yield: 79%)