Phenyl Isothiocyanate → HCID 20366882, compound

HRID 616896Notes

Reaction equation

HRID 616896 reaction equation
[NH2:1][CH:2]1[CH2:11][CH:10]2[N:5]([CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=32)[CH2:4][CH2:3]1.[C:16]1([N:22]=[C:23]=[S:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1C=CC=CC=1>[CH2:11]1[CH:10]2[N:5]([CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=32)[CH2:4][CH2:3][CH:2]1[NH:1][C:23]([NH:22][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[S:24]

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 129401711,3,4,6,7,11b-Hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Product 1

HCID 20366882HCID 20366882, compoundYield 56.7%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2-Amino-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizine (0.766 g) and phenyl isothiocyanate (0.563 g) were condensed together in benzene (50 ml) in a manner analogous to that of Example 1 to give the title compound (0.724 g). Crystallization from EtOH/HCl afforded the hydrochloride (0.950 g), m.p. 213.5° C. C20H23N3S.HCl requires C, 64.25; H, 6.47; N, 11.24% Found: C, 63.94; H, 6.56; N, 11.16%.

Sources & evidence

ORD record
ord-56374b4bd7dc46bfba4a9cc06559c40f
Source dataset
uspto-grants-1978_02
Patent number
US04076820

Reaction notes

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