Potassium Iodide → HCID 20382001, compound

HRID 616952Notes

Reaction equation

HRID 616952 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Br)=[CH:5][CH:4]=1.[I-].[K+].[OH:13][CH2:14][C:15]1[CH:27]=[C:26]2[N:17]([C:18](=[O:28])[NH:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:25]=32)[N:16]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:13][CH2:14][C:15]1[CH:27]=[C:26]2[N:17]([C:18](=[O:28])[N:19]([CH2:7][C:6]3[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:25]=32)[N:16]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 1650214-Methoxybenzyl bromideHCID 135449340Pirquinozol

Product 1

HCID 20382001HCID 20382001, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

210 g of p-methoxybenzyl bromide and 40 g of potassium iodide are added to 114 g of 2-(hydroxymethyl)pyrazolo[1,5-c]-quinazolin-5(6H)-one and 276 g of potassium carbonate in 2 1. of methanol. After refluxing for 5 hours, the reaction is cooled, poured into 6 1. of water and the title compound is filtered off and dried.

Workup

  1. temperatureAfter refluxing for 5 hours
  2. temperaturethe reaction is cooled
  3. additionpoured into 6 1
  4. filtrationof water and the title compound is filtered off
  5. customdried

Sources & evidence

ORD record
ord-bc98a652782342838fa97f3ccf23821e
Source dataset
uspto-grants-1978_02
Patent number
US04076818

Reaction notes

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