Dimethylamine → HCID 178456694, compound

HRID 617011Notes

Reaction equation

HRID 617011 reaction equation
C(O[C:4]([NH:6][N:7]([CH:10]([CH3:12])[CH3:11])[C:8]#[N:9])=[O:5])C.[CH3:13][NH:14][CH3:15]>C(O)C>[CH:10]([N:7]1[C:8]([N:14]([CH3:15])[CH3:13])=[N:9][C:4]([OH:5])=[N:6]1)([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19390523HCID 19390523, compound

Product 1

HCID 178456694HCID 178456694, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

35.0 g of 2-isopropyl-2-cyanohydrazinecarboxylic acid ethyl ester is added dropwise to a solution of 100 ml of 33% dimethylamine in absolute ethanol. The solution is maintained firstly for 15 hours at room temperature and afterwards for 1 1/2 hours at reflux temperature (65° C). After concentration by evaporation to dryness there remains an oily residue, which slowly crystallises on standing. The semisolid product is washed with ethyl acetate. There is obtained 15.5 g (44% of theory) of 1-isopropyl-5-dimethylamino-3-hydroxy-1,2,4-triazole, m.p. 111°-112° C.

Workup

  1. temperatureat reflux temperature (65° C)
  2. concentrationAfter concentration
  3. customby evaporation to dryness
  4. customslowly crystallises
  5. washThe semisolid product is washed with ethyl acetate

Sources & evidence

ORD record
ord-c85c8adabeb546b6b1b417ef6b15dcaa
Source dataset
uspto-grants-1978_02
Patent number
US04076938

Reaction notes

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