Dimethylamine → HCID 178456694, compound

Participants

Reaction Steps

35.0 g of 2-isopropyl-2-cyanohydrazinecarboxylic acid ethyl ester is added dropwise to a solution of 100 ml of 33% dimethylamine in absolute ethanol. The solution is maintained firstly for 15 hours at room temperature and afterwards for 1 1/2 hours at reflux temperature (65° C). After concentration by evaporation to dryness there remains an oily residue, which slowly crystallises on standing. The semisolid product is washed with ethyl acetate. There is obtained 15.5 g (44% of theory) of 1-isopropyl-5-dimethylamino-3-hydroxy-1,2,4-triazole, m.p. 111°-112° C.

Provenance & Evidence