HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → 2-amino-N-(4-methoxy-phenyl)-3-methoxy-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | 8-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione | HCID 10559679 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-amino-N-(4-methoxy-phenyl)-3-methoxy-benzamide | HCID 18174430 | — |
Reaction Steps
To a solution of 27.17 g (0.141 mol) of 8-methoxyisatoic anhydride in 200 mL of ethanol was added a catalytic amount of 4-dimethylaminopyridine and 350 mL of a 1M solution containing 43.0 g (0.350 mol) of p-anisidine. The reaction mixture was stirred and heated under reflux overnight. The reaction flask was then chilled on ice. The precipitate that formed was collected by vacuum filtration and amounted to 34.7 g. An analytical sample (mp 168-169° C.) was obtained by recrystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948775 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-f72bda8dcd30406794af07be74c69540 |
| Source note | uspto-grants-1999_09 |