Methyl iodide → HCID 53636566, compound

HRID 617138Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:13][OH:14])[CH:10]([CH3:12])[CH3:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15]I>>[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:13][O:14][CH3:15])[CH:10]([CH3:11])[CH3:12])=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 11241137Boc-D-valinol

Product 1

HCID 53636566HCID 53636566, compoundYield 67%

Procedure

The title compound has been prepared in 67% yield from the alcohol of Example 6, Step B and methyl iodide following the alkylation method given in Example 6, Step C. Rf: 0.27 (silica gel, ethyl acetate/petroleum ether: 1/9).

Sources & evidence

ORD record: ord-80da9f7ca8174d6193da012395a78f3d
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948778

Reaction notes

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