HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → 3-[1-(6-Ethoxy-7-isopropoxy-2-morpholino-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 3-[1-(6-Ethoxy-7-hydroxy-2-morpholino-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazoline | HCID 135822834 | — |
| Product | 3-[1-(6-Ethoxy-7-isopropoxy-2-morpholino-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazoline | HCID 21851303 | 31% |
Reaction Steps
The same procedure as in Example 48 was repeated, using 335 mg (0.61 mmol) of Compound 47 obtained in Example 47, except that isopropyl iodide was used in place of methyl iodide, to give 112 mg (yield: 31%) of Compound 50 as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948784 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-c027f258b69c4b92886960b0b8085b9f |
| Source note | uspto-grants-1999_09 |