反应详情

In 30 ml of methanol was dissolved 900 mg (1.42 mmol) of Compound 54 obtained in Example 54, 15 ml of 2N-sodium hydroxide was added, and the mixture was stirred under heating at reflux for 4 hour. After cooling, 4N-hydrochloric acid was added to the reaction mixture and the mixtute was neutralized and subjected to extraction with chloroform. The organic layer was washed, dried and concentrated to give the residue. Ether was added to the above residue to give the precipitate which was collected by filtration and dried to give 870 mg (yield: 100%) of Compound 56 as white crystals.

1. additionwas added
2. temperatureunder heating
3. temperatureat reflux for 4 hour
4. temperatureAfter cooling
5. extractionsubjected to extraction with chloroform
6. washThe organic layer was washed
7. customdried
8. concentrationconcentrated
9. customto give the residue
10. customto give the precipitate which
11. filtrationwas collected by filtration
12. customdried