反应详情

To a solution of 2-amino-4-(4-piperidinyl)quinazoline (100 mg, 0.44 mmol) obtained in Example 11(1) and triethylamine (133 mg, 1.3 mmol) in dichloromethane (50 ml) was added phenyl isocyanate (50 mg, 0.42 mmol) under a nitrogen atmosphere. The mixture was stirred for about 3 hours at room temperature. The reaction mixture was washed with saturated sodium hydrogencarbonate aqueous solution. The organic layer was dried over sodium sulfate and evaporated in vacuo. The residue was purified by silicagel column chromatography (chloroform:methanol=99:1) to give the titled compound (127 mg).

1. washThe reaction mixture was washed with saturated sodium hydrogencarbonate aqueous solution
2. dry with materialThe organic layer was dried over sodium sulfate
3. customevaporated in vacuo
4. customThe residue was purified by silicagel column chromatography (chloroform:methanol=99:1)