1,4-Dioxane hydrochloride → HCID 21851544, compound

Participants

Reaction Steps

To a solution of 2-amino-4-[1-(7-t-butoxycarbonylaminoheptanoyl)-4-piperidinyl]quinazoline (160 mg) obtained in Example 27 in tetrahydrofuran (1 ml) was added 4N hydrogen chloride-dioxane solution (1 ml). The reaction mixture was stirred for about 1 hour at room temperature and was evaporated. The residue was triturated with diethyl ether to give the title compound (131 mg) as hydrochloride.

Provenance & Evidence