1,4-Dioxane hydrochloride → HCID 21851544, compound

HRID 617183Notes

Reaction equation

HRID 617183 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([CH:12]2[CH2:17][CH2:16][N:15]([C:18](=[O:33])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][NH:25]C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl.O1CCOCC1>O1CCCC1>[NH2:1][C:2]1[N:11]=[C:10]([CH:12]2[CH2:17][CH2:16][N:15]([C:18](=[O:33])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21851525HCID 21851525, compound

Product 1

HCID 21851544HCID 21851544, compoundYield 104.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-amino-4-[1-(7-t-butoxycarbonylaminoheptanoyl)-4-piperidinyl]quinazoline (160 mg) obtained in Example 27 in tetrahydrofuran (1 ml) was added 4N hydrogen chloride-dioxane solution (1 ml). The reaction mixture was stirred for about 1 hour at room temperature and was evaporated. The residue was triturated with diethyl ether to give the title compound (131 mg) as hydrochloride.

Workup

  1. customwas evaporated
  2. customThe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-8fe8fad18c1d44bfae0e760a0915b7c6
Source dataset
uspto-grants-1999_09
Patent number
US05948786

Reaction notes

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