Hydrochloric Acid → HCID 21851535, compound

HRID 617184Notes

Reaction equation

Cl.[NH2:2][C:3]1[N:12]=[C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:35])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27]C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1>>[NH2:2][C:3]1[N:12]=[C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:35])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])[CH2:15][CH2:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21851509HCID 21851509, compound

Product 1

HCID 21851535HCID 21851535, compoundYield 115.7%

Procedure

By a procedure similar to that described in Example 284, the titled compound (91 mg) as hydrochloride was prepared from 2-amino-4-[1-(8-t-butoxycarbonylaminooctanoyl)-4-piperidinyl]quinazoline (100 mg) obtained in Example 28.

Sources & evidence

ORD record: ord-218dd9c4fd4b4b8ebcc7dcccb21edfad
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948786

Reaction notes

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