Hydrochloric Acid → HCID 21851542, compound

HRID 617185Notes

Reaction equation

HRID 617185 reaction equation
Cl.[NH2:2][C:3]1[N:12]=[C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:38])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][NH:30]C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1>>[NH2:2][C:3]1[N:12]=[C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:38])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][NH2:30])[CH2:15][CH2:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21851513HCID 21851513, compound

Product 1

HCID 21851542HCID 21851542, compoundYield 95.1%

Procedure

By a procedure similar to that described in Example 284, the titled compound (130 mg) as hydrochloride was prepared from 2-amino-4-[1-(11-t-butoxycarbonylaminoundecanoyl)-4-piperidinyl]quinazoline (170 mg) obtained in Example 29.

Sources & evidence

ORD record
ord-b5ad5fad4441438c98ff10e63311b9bb
Source dataset
uspto-grants-1999_09
Patent number
US05948786

Reaction notes

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