Hydrochloric Acid → HCID 21851540, compound

HRID 617186Notes

Reaction equation

HRID 617186 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([CH:9]2[CH2:14][CH2:13][N:12]([C:15](=[O:26])[CH2:16][CH2:17][NH:18]C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:6]=[C:5]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[N:4]=1>>[NH2:2][C:3]1[N:8]=[C:7]([CH:9]2[CH2:10][CH2:11][N:12]([C:15](=[O:26])[CH2:16][CH2:17][NH2:18])[CH2:13][CH2:14]2)[CH:6]=[C:5]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[N:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21851537HCID 21851537, compound

Product 1

HCID 21851540HCID 21851540, compoundYield 94.9%

Procedure

By a procedure similar to that described in Example 284, the titled compound (127 mg) as hydrochloride was prepared from 2-amino-4-[1-(3-t-butoxycarbonylaminopropanoyl)-4-piperidinyl]-6-(4-methoxyphenylmethyl)pyrimidine (170 mg) obtained in Example 176.

Sources & evidence

ORD record
ord-1c46bfda51a9436198a913bc3bc29e96
Source dataset
uspto-grants-1999_09
Patent number
US05948786

Reaction notes

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