Hydrochloric Acid → HCID 21851186, compound

HRID 617224Notes

Reaction equation

HRID 617224 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([CH2:15][CH2:16][C:17]1[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=1)[C:7]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:6]2[C:28]1[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([O:36][CH3:37])[CH:29]=1.[ClH:38].CCOCC>C(O)C>[ClH:38].[ClH:38].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([CH2:15][CH2:16][C:17]1[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=1)[C:7]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:6]2[C:28]1[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([O:36][CH3:37])[CH:29]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 9957824HCID 9957824, compound

Product 1

HCID 21851186HCID 21851186, compoundYield 88.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-[2- (1-methylimidazol-2-yl)ethyl]quinoline-3-carboxylate (9.0 g) was suspended in ethanol (40 ml), and ethanolic hydrogen chloride (22%, 10 g) was added. The mixture was stirred at room temperature for 5 minutes. Ether (150 ml) was added, and the deposited crystals were separated by filtration and recrystallized from ethanol/ether to obtain ethyl 6,7- dimethoxy-4-(3,4-dimethoxyphenyl)-2-[2-(1-methylimidazol-2- yl)ethyl]quinoline-3-carboxylate dihydrochloride (9.1 g).

Workup

  1. customthe deposited crystals were separated by filtration
  2. customrecrystallized from ethanol/ether

Sources & evidence

ORD record
ord-f6c689da16a44721978526f931031112
Source dataset
uspto-grants-1999_09
Patent number
US05948782

Reaction notes

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