Hydrochloric Acid → 6,6-Dimethyl-11-oxo-8-(2-oxo-2-piperazin-1-yl-ethoxy)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloric acid salt

HRID 61726Notes

Reaction equation

HRID 61726 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:39])[CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]3[C:32](=[O:33])[C:31]4[C:30]5[C:25](=[CH:26][C:27]([C:34]#[N:35])=[CH:28][CH:29]=5)[NH:24][C:23]=4[C:22]([CH3:37])([CH3:36])[C:21]=3[CH:38]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:40].O1CCOCC1>O>[ClH:40].[CH3:36][C:22]1([CH3:37])[C:23]2[NH:24][C:25]3[C:30](=[CH:29][CH:28]=[C:27]([C:34]#[N:35])[CH:26]=3)[C:31]=2[C:32](=[O:33])[C:20]2[CH:19]=[CH:18][C:17]([O:16][CH2:15][C:14](=[O:39])[N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:38][C:21]1=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668341864-[2-(3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yloxy)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 668341186,6-Dimethyl-11-oxo-8-(2-oxo-2-piperazin-1-yl-ethoxy)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloric acid salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

4-[2-(3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yloxy)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester (Compound A9-15-1, 20 mg) was added with 4 N hydrochloric acid and dioxane solution (1 ml), and stirred in an water bath at 10° C. for 4 hr. Water was added to the reaction solution and the resulting precipitates were filtered and dried to obtain the title compound (15 mg, white powder).

Workup

  1. customthe resulting precipitates
  2. filtrationwere filtered
  3. customdried

Sources & evidence

ORD record
ord-ca07e01d83644f85b03bea49b56a6b0c
Source dataset
uspto-grants-2016_09
Patent number
US09440922B2

Reaction notes

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