HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 5-chloro-3-((1-methyl-2-(R)-pyrrolidinyl)methoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | (R)-tert-butyl 2-((5-chloropyridin-3-yloxy)methyl)pyrrolidine-1-carboxylate | HCID 21309710 | — |
| Reactant | 3-Chloro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine | HCID 44318981 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 5-chloro-3-((1-methyl-2-(R)-pyrrolidinyl)methoxy)pyridine | HCID 54149977 | — |
Reaction Steps
Following the procedure of Example 16a, replacing the 5-chloro-3-(N-t-butoxycarbonyl-2-S)-pyrrolidinylmethoxy)pyridine thereof with 5-chloro-3-(N-t-butoxycarbonyl-2-(R)-pyrrolidinylmethoxy)pyridine (prepared from the (R)-isomer of the starting material following the procedure of Example 15a), the tide compound was prepared. TLC Rf =0.23 (10% MeOH/CHCl3). MS and 1H NMR (CDCl3, 300 MHz) are similar to 16a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948793 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-1af3f47d8cce4af389c7692eae79faaf |
| Source note | uspto-grants-1999_09 |