Hydrochloric Acid → 2-methyl-3-(2-pyrrolidinylmethoxy)pyridine dihydrochloride, (R)-

HRID 617311Notes

Reaction equation

HRID 617311 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:15].CC1C(OC[C@@H]2CCCN2)=CC=CN=1>CO>[ClH:15].[ClH:15].[CH3:1][C:2]1[C:7]([O:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 127922(R)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridineHCID 178052Pozanicline

Product 1

HCID 702036652-methyl-3-(2-pyrrolidinylmethoxy)pyridine dihydrochloride, (R)-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of step 35a was treated with HCl and isolated as described in Example 1b to give a white powder. MS and 1H NMR (D2O, 300 Hz) are similar to 17b. Anal. Calc for C11H16N2O.2.00 HCl: C, 48.82; H, 6.84; N, 10.56; Found C, 49.55; H, 6.95; N, 10.52. [α]25D =- 27.01° (c=1, MeOH).

Workup

  1. customisolated
  2. customto give a white powder

Sources & evidence

ORD record
ord-8a8653ca04884c5fae148a74fb4d1299
Source dataset
uspto-grants-1999_09
Patent number
US05948793

Reaction notes

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