反应详情

温度

-23 °C

A 7.5 g sample of the compound from step 72a was dissolved in 140 mL of DMF and 2.2 g of imidazole was added. The solution was cooled to -23° C., and 4.84 g of t-butyldimethylsilyl chloride was added and stirred for 1 hour. The volatiles were removed under vacuum, and the residue was purified on a silica gel column, eluting with 1:2 ethyl acetate:hexane to give 8.05 g of the title compound.

1. customThe volatiles were removed under vacuum
2. customthe residue was purified on a silica gel column
3. washeluting with 1:2 ethyl acetate