HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → methoxy-N-methylphenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-Methoxy-3-isochromanone | HCID 15547285 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methoxy-N-methylphenylacetamide | HCID 15642519 | 96.5% |
| Product | 2-hydroxymethyl-alpha-methoxy-N-methyl-phenylacetamide | HCID 70239316 | — |
Reaction Steps
40% methylamine--methanol solution (9.80 g, 126 mmol) was added to 4-methoxy-3-isochromanone (7.50 g, 42.1 mmol) in methanol (40 ml), and the mixture was stirred at room temperature for 1 hour. Evaporation of the solvent gave the desired compound 2-hydroxymethyl-(α-methoxy-N-methylphenyl-acetamide (8.50 g, 96.5%) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948819 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-5e57fcad33804ae29438ebb077638b22 |
| Source note | uspto-grants-1999_09 |