Sodium Hydroxide → HCID 21852183, compound

HRID 617416Notes

Reaction equation

HRID 617416 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:17]=[CH:16][C:12]3[O:13][CH2:14][O:15][C:11]=3[C:10]=2[C:18]([O:20]C)=[O:19])=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:17]=[CH:16][C:12]3[O:13][CH2:14][O:15][C:11]=3[C:10]=2[C:18]([OH:20])=[O:19])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86754440HCID 86754440, compound

Product 1

HCID 21852183HCID 21852183, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The crude 5-(4-methoxyphenyl)-(1,3)-benzodioxole-4-carboxylic acid, methyl ester was hydrolyzed with 1 N sodium hydroxide (2 mL) in refluxing ethanol (10 mL) until TLC analysis indicated the completion of the reaction. The cooled reaction mixture was extracted with methylene chloride and then the aqueous layer was acidified with 1 N hydrochloric acid. The acidic solution was extracted with methylene chloride and the organic layers were dried and concentrated by rotary evaporation to give the crude acid.

Workup

  1. customthe completion of the reaction
  2. customThe cooled reaction mixture
  3. extractionwas extracted with methylene chloride
  4. extractionThe acidic solution was extracted with methylene chloride
  5. customthe organic layers were dried
  6. concentrationconcentrated by rotary evaporation

Sources & evidence

ORD record
ord-a4d61a1e2e0545cd9dcf51d62eaabc47
Source dataset
uspto-grants-1999_09
Patent number
US05948817

Reaction notes

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