Sodium Hydroxide → HCID 21852183, compound

Participants

Reaction Steps

The crude 5-(4-methoxyphenyl)-(1,3)-benzodioxole-4-carboxylic acid, methyl ester was hydrolyzed with 1 N sodium hydroxide (2 mL) in refluxing ethanol (10 mL) until TLC analysis indicated the completion of the reaction. The cooled reaction mixture was extracted with methylene chloride and then the aqueous layer was acidified with 1 N hydrochloric acid. The acidic solution was extracted with methylene chloride and the organic layers were dried and concentrated by rotary evaporation to give the crude acid.

Provenance & Evidence