HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 4-(4-Chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate | HCID 23289523 | — |
| Product | 4-(4-Chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester | HCID 15840514 | — |
Reaction Steps
A mixture of POCl3 (18 ml) with 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester (6 g) is refluxed 4 hours under the addition of N,N-dimethylaniline (1.8 ml). The usual workup yields 4-(4-chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester (5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948911 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-f40b423258c64ac7898d6d1a41e43dcb |
| Source note | uspto-grants-1999_09 |