反应详情

A mixture of POCl3 (18 ml) with 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester (6 g) is refluxed 4 hours under the addition of N,N-dimethylaniline (1.8 ml). The usual workup yields 4-(4-chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester (5 g).