HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[4-(3,4-Methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d-]pyrimidin-2-yl]-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[4-(3,4-Methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester | HCID 9802915 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[4-(3,4-Methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d-]pyrimidin-2-yl]-benzoic acid | HCID 9888324 | 70.5% |
Reaction Steps
A solution of 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester (1.1 g), 2N NaOH (30 ml), and tetrahydrofuran (30 ml) is heated 6hours to 100° C. After cooling and acidifing the solution with 20% HCl, the usual work up yields 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d-]pyrimidin-2-yl]-benzoic acid (0.75 g), Mp. >250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948911 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-e8998f2db66648f0a63f6a47ea449fff |
| Source note | uspto-grants-1999_09 |