反应详情

A solution of 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester (1.1 g), 2N NaOH (30 ml), and tetrahydrofuran (30 ml) is heated 6hours to 100° C. After cooling and acidifing the solution with 20% HCl, the usual work up yields 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d-]pyrimidin-2-yl]-benzoic acid (0.75 g), Mp. >250° C.

1. temperatureAfter cooling