Diethyl methylmalonate → Diethyl 2-(2-(2-benzyloxyphenyl)ethyl)-2-methylmalonate

HRID 617589Notes

Reaction equation

HRID 617589 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[CH:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2].[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28]I)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28][C:5]([CH3:11])([C:4]([O:3][CH2:1][CH3:2])=[O:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 11857Diethyl methylmalonateHCID 226187172-(2-Benzyloxyphenyl)ethyl iodide

Product 1

HCID 22618873Diethyl 2-(2-(2-benzyloxyphenyl)ethyl)-2-methylmalonate

Procedure

2-Methylmalonic acid diethyl ester and 2-(2-benzyloxyphenyl)ethyl iodide were used in the same manner as working example 52 (3) to give the subject compound.

Workup

  1. customto give the subject compound

Sources & evidence

ORD record
ord-dcfc892577e74c188adc4d52104c2ac9
Source dataset
uspto-grants-1999_09
Patent number
US05948820

Reaction notes

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