Diethyl ethylmalonate → 2-Amino-2-ethyl-4-[4-(1-hydroxyoctyl)phenyl]butanol

HRID 617601Notes

Reaction equation

HRID 617601 reaction equation
C([O:4][CH2:5][C:6]([NH:26]C(=O)C)([CH2:24][CH3:25])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][CH:10]=1)(=O)C.C(OC(=O)C(CC)C(OCC)=O)C>>[NH2:26][C:6]([CH2:24][CH3:25])([CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]([OH:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:13][CH:14]=1)[CH2:5][OH:4]

Participants

3

Reactant 2

HCID 8610Diethyl ethylmalonateHCID 53718772HCID 53718772, compound

Product 1

HCID 226187962-Amino-2-ethyl-4-[4-(1-hydroxyoctyl)phenyl]butanol

Procedure

In working example 77, 2-acetamido-2-ethyl-4-(4-octanoylphenyl)butyl acetate obtained by using ethylmalonic acid diethyl ester instead of propylmalonic acid diethyl ester, is treated in the same manners as working example 79 and then working example 80 to give the subject compound.

Workup

  1. customobtained
  2. additionis treated in the same manners
  3. customto give the subject compound

Sources & evidence

ORD record
ord-46539a9f00db4d518e5ff82697b519a2
Source dataset
uspto-grants-1999_09
Patent number
US05948820

Reaction notes

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