Hydrochloric Acid → Ethyl thiophene-2-carboximidate hydrochloride

HRID 617646Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].[ClH:8].[CH2:9]([OH:11])[CH3:10]>>[ClH:8].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[NH:7])[O:11][CH2:9][CH3:10]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 660872-Thiophenecarbonitrile

Product 1

HCID 12231044Ethyl thiophene-2-carboximidate hydrochloride

Procedure

Ethyl 2-thiophenecarboximidate hydrochloride was synthesized in the same manner as in Reference Example 2. That is, 2-thiophenecarbonitrile (25.2 g, 0.231 mol) was treated with hydrogen chloride in ethanol (250 mL) to give 16.3 g (37%) of the target compound as colorless crystals.

Sources & evidence

ORD record: ord-80ce5be320a941bda7e49048bcaa9e1d
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948785

Reaction notes

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