Hydrochloric Acid → HCID 18391677, compound

HRID 617665Notes

Reaction equation

HRID 617665 reaction equation
C(OC([NH:8][C@@H:9]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C@@H:10]([OH:19])[C:11]([F:18])([F:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=O)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[NH2:8][C@@H:9]([CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C@@H:10]([OH:19])[C:11]([F:17])([F:18])[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12086024HCID 12086024, compound

Product 1

HCID 18391677HCID 18391677, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Ethyl 4(S)-amino-2,2-difluoro-3(R)-hydroxy-5-phenylpentanoate hydrochloride was synthesized in the same manner as in Example 83-(7). That is, ethyl 4(S)-[(tert-butoxycarbonyl)amino]-2,2-difluoro-3(R)-hydroxy-5-phenylpentanoate (an intermediate in Reference Example 6, 908 mg, 2.43 mmol) was treated with a solution of hydrogen chloride in 1,4-dioxane (4N, 6 mL) to give 750 mg (100%) of the target compound as a colorless solid.

Sources & evidence

ORD record
ord-efd867f438884e518346a7c40254bd76
Source dataset
uspto-grants-1999_09
Patent number
US05948785

Reaction notes

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