反应详情

Ethyl 4(S)-amino-2,2-difluoro-3(R)-hydroxy-5-phenylpentanoate hydrochloride was synthesized in the same manner as in Example 83-(7). That is, ethyl 4(S)-[(tert-butoxycarbonyl)amino]-2,2-difluoro-3(R)-hydroxy-5-phenylpentanoate (an intermediate in Reference Example 6, 908 mg, 2.43 mmol) was treated with a solution of hydrogen chloride in 1,4-dioxane (4N, 6 mL) to give 750 mg (100%) of the target compound as a colorless solid.