HCID 70068774, compound → HCID 18391848, compound

HRID 617756Notes

Reaction equation

HRID 617756 reaction equation
[CH2:1]([C:3]1([CH2:32][CH3:33])[C@H:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[CH:10][CH:9]=2)[N:5]([C:17]([NH:19][C@H:20]([CH2:28][CH:29]=[CH2:30])[C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)=[O:18])[C:4]1=[O:31])[CH3:2]>[Pd].C(O)C>[CH2:32]([C:3]1([CH2:1][CH3:2])[C@H:6]([O:7][C:8]2[CH:9]=[CH:10][C:11]([C:14](=[O:16])[CH3:15])=[CH:12][CH:13]=2)[N:5]([C:17]([NH:19][C@H:20]([CH2:28][CH2:29][CH3:30])[C:21]2[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=2)=[O:18])[C:4]1=[O:31])[CH3:33]

Participants

4

Reactant 1

HCID 70068774HCID 70068774, compound

Product 1

HCID 18391848HCID 18391848, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of (4S)-3,3-diethyl-1-[(R)-α-allyl-(4-methyl)benzylaminocarbonyl]-4-[(4-acetyl)phenoxy]azetidin-2-one (1.3 gm, 2.9 mmol) and 100 mg of 10% palladium on carbon in ethanol (15 mL) was hydrogenated at 40 p.s.i. for 20 min. The reaction was then filtered and evaporated to afford 1.3 gm (quantitative) of clean title compound without further purification.

Workup

  1. filtrationThe reaction was then filtered
  2. customevaporated

Sources & evidence

ORD record
ord-cf6be66ad26f46d8879ed318bf926b8e
Source dataset
uspto-grants-1999_09
Patent number
US05952321

Reaction notes

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