反应详情

2-Amino-4-hydroxy-6-tert-butylpyrimidine (8.35 g) was dissolved in 50 mL of phosphorus oxychloride and the solution refluxed for 2 hours. Excess phosphorus oxychloride was removed under vacuum and the residue dissolved in 100 mL of ethanol. The solution was adjusted to pH 8 with ice-cold concentrated ammonium hydroxide, and solvent removed under reduced pressure. The residue was filtered to give a white solid, which was recrystallized from ethanol-water to give 2-amino-4-chloro-6-tert-butylpyrimidine (3.66 g), m.p. 87.7-88.90° C.

1. temperaturethe solution refluxed for 2 hours
2. customExcess phosphorus oxychloride was removed under vacuum
3. dissolutionthe residue dissolved in 100 mL of ethanol
4. customremoved under reduced pressure
5. filtrationThe residue was filtered
6. customto give a white solid, which
7. customwas recrystallized from ethanol-water