Fingolimod → Fingolimod Hydrochloride

HRID 617847Notes

Reaction equation

HRID 617847 reaction equation
[NH2:1][C:2]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][CH:10]=1)([CH2:5][OH:6])[CH2:3][OH:4].[ClH:23].CCOCC>C(O)C>[ClH:23].[NH2:1][C:2]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][CH:10]=1)([CH2:5][OH:6])[CH2:3][OH:4]

Participants

4

Reactant 2

HCID 107970FingolimodHCID 10953452Ether hydrochloride

Product 1

HCID 107969Fingolimod Hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol (7 g) was dissolved in ethanol (50 ml) and a 1 N hydrochloric acid/ether solution (50 ml) was added thereto. The solvent was distilled away and the resultant crystals were recrystallized from ethanol to give 4.2 g of the subject compound.

Workup

  1. distillationThe solvent was distilled away
  2. customthe resultant crystals were recrystallized from ethanol

Sources & evidence

ORD record
ord-af1d16095e434800ae3b3fe9d4eec219
Source dataset
uspto-grants-1999_09
Patent number
US05952316

Reaction notes

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