HCID 53886611, compound → HCID 53671633, compound

HRID 617897Notes

Reaction equation

HRID 617897 reaction equation
[CH2:1]([CH:8]([O:10][P:11]([CH2:14][C:15]1([C:20]([OH:22])=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16]1)([OH:13])=[O:12])C)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:8]([O:10][P:11]([CH2:14][C:15]1([C:20]([OH:22])=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19]1)([OH:13])=[O:12])[CH3:1]

Participants

5

Reactant 2

HCID 53886611HCID 53886611, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53671633HCID 53671633, compoundYield 102.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3.5 g of 1-benzylethylphosphonomethyl-1-cyclopentanecarboxylic acid (preparation see Example 3E)) were dissolved in 150 ml of ethanol and treated with 1.0 g of 5% strength Pd catalyst on active carbon. The mixture was then hydrogenated at a hydrogen pressure of 2.1 bar for 4 hours. The catalyst was filtered out twice, the filtrate was evaporated in vacuo, and the residue was dried in a high vacuum. 2.60 g of oily 1-ethylphosphonomethyl-1-cyclopentanecarboxylic acid were obtained, which was reacted without further purification.

Workup

  1. filtrationThe catalyst was filtered out twice
  2. customthe filtrate was evaporated in vacuo
  3. customthe residue was dried in a high vacuum

Sources & evidence

ORD record
ord-d57b147a5f014eec86bcf250b7aa5554
Source dataset
uspto-grants-1999_09
Patent number
US05952327

Reaction notes

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