Formaldehyde → Diethyl phosphonomethanol

HRID 617898Notes

Reaction equation

HRID 617898 reaction equation
[P:1]([O-:8])([O:5][CH2:6][CH3:7])[O:2][CH2:3][CH3:4].[CH2:9]=[O:10]>C(N(CC)CC)C>[OH:10][CH2:9][P:1](=[O:8])([O:5][CH2:6][CH3:7])[O:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 3780918Diethylphosphite

Product 1

HCID 76513Diethyl phosphonomethanolYield 81.3%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

69.05 g of diethyl phosphite were reacted with 14.5 g of paraformaldehyde and 6.96 ml of triethylamine analogously to the process described in Example 1A). 66.02 g of diethyl hydroxymethylphosphonate were obtained which, after drying in a high vacuum, was reacted further without additional purification.

Sources & evidence

ORD record
ord-4681e66f69af4f64b7596eabdbc90932
Source dataset
uspto-grants-1999_09
Patent number
US05952327

Reaction notes

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