HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → Diisopropyl hydroxymethylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Phosphorous acid, bis(1-methylethyl) ester | HCID 21884976 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Diisopropyl hydroxymethylphosphonate | HCID 10867235 | 67.5% |
Reaction Steps
50.0 g of diisopropyl phosphite, 8.5 g of paraformaldehyde and 4.0 ml of triethylamine were reacted according to the method indicated in Example 1A). Chromatography of the crude product on silica gel (eluent: n-hexane/ethyl acetate 1:4) yielded 37.5 g of diisopropyl hydroxymethylphosphonate as an oil, which was reacted further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952327 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-2f4441f1744f41ee88c6ae8dc67b45b4 |
| Source note | uspto-grants-1999_09 |