反应详情

50.0 g of diisopropyl phosphite, 8.5 g of paraformaldehyde and 4.0 ml of triethylamine were reacted according to the method indicated in Example 1A). Chromatography of the crude product on silica gel (eluent: n-hexane/ethyl acetate 1:4) yielded 37.5 g of diisopropyl hydroxymethylphosphonate as an oil, which was reacted further without purification.