HCID 12017171, compound → HCID 12017172, compound

HRID 617906Notes

Reaction equation

HRID 617906 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[CH:24]=[CH:23][C:22]3[CH2:21][CH2:20][CH2:19][NH:18][C:17]=3[N:16]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.Cl.O1CCOCC1>O1CCOCC1>[N:16]1[C:17]2[NH:18][CH2:19][CH2:20][CH2:21][C:22]=2[CH:23]=[CH:24][C:15]=1[CH2:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 12017171HCID 12017171, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 12017172HCID 12017172, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-4 (1.6 g, 4.8 mmol) and dioxane (24 mL) at 0oC was treated with 4M HCl/dioxane (6.0 mL) followed by removal of the cooling bath. After 5 hr the reaction mixture was concentrated to give 3-5 as a yellow solid.

Workup

  1. customfollowed by removal of the cooling bath
  2. concentrationAfter 5 hr the reaction mixture was concentrated

Sources & evidence

ORD record
ord-0b178d379b864aecabac249967196012
Source dataset
uspto-grants-1999_09
Patent number
US05952341

Reaction notes

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