Potassium Carbonate → HCID 21850091, compound

HRID 617913Notes

Reaction equation

HRID 617913 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:18][CH3:19])=[CH:15][CH:16]=3)[CH:11]=[CH:10][C:9]=2[C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[CH:5]=[CH:6][CH:7]=1.Cl.Cl[CH2:30][CH2:31][CH2:32][N:33]1[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1.C([O-])([O-])=O.[K+].[K+]>>[CH3:27][O:26][C:23]1[CH:24]=[CH:25][C:20]([C:9]2[CH:10]=[CH:11][C:12]3[C:17](=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=3)[C:8]=2[C:4]2[CH:3]=[C:2]([O:1][CH2:30][CH2:31][CH2:32][N:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)[CH:7]=[CH:6][CH:5]=2)=[CH:21][CH:22]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 79624N-(3-chloropropyl)piperidine hydrochlorideHCID 218500951-(3-Hydroxyphenyl)-2-(4-methoxyphenyl)-6-methoxynaphthalene

Product 1

HCID 21850091HCID 21850091, compoundYield 92.4%

Procedure

In a manner similar to that used in Example 2, 1.04 g (2.9 mmol) of 1-(3-hydroxyphenyl)-2-(4-methoxyphenyl)-6-methoxynaphthalene, 0.86 g (4.35 mmol) of 1-(3-chloropropyl)piperidine hydrochloride, and 2 g (14.4 mmol) of K2CO3 were converted to 1.29 g of the title compound, isolated as a brown oil.

Sources & evidence

ORD record
ord-7f7fe27366ba4957a15bfc30876c526b
Source dataset
uspto-grants-1999_09
Patent number
US05952350

Reaction notes

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