Hydrochloric Acid → HCID 178418440, compound

HRID 617919Notes

Reaction equation

HRID 617919 reaction equation
Cl.S(OS([O-])(=O)=O)([O-])(=O)=[O:3].[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](N)=[N:18][C:16]=2[N:17]=1>O>[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([OH:3])=[N:18][C:16]=2[N:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 177717DisulfateHCID 108474752,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

Product 1

HCID 178418440HCID 178418440, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 2 L of concentrated HCl and 1 L of water is added 300 g of the disulfate salt of 2,7-diamino-6-phenylpyrido[2,3-d]pyrimidine and the resulting mixture refluxed with stirring overnight The reaction mixture is cooled in an ice bath, filtered, and the insoluble product washed with water, followed by ethanol to give 149 g of the title compound 2-amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-ol, mp 390-395° C. (darkens slowly above 350° C.).

Workup

  1. temperaturethe resulting mixture refluxed
  2. temperatureis cooled in an ice bath
  3. filtrationfiltered
  4. washthe insoluble product washed with water

Sources & evidence

ORD record
ord-6877414ef5b44519bcdd4a0e2a3ef28d
Source dataset
uspto-grants-1999_09
Patent number
US05952342

Reaction notes

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