反应详情

温度

90 °C

7-Methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one (Compound A2, 3.37 g, 16.5 mmol) was dissolved in CH3CN (82 mL), added with NCS (2.42 g, 1.1 eq.) and stirred at 90° C. for 1.5 hr. The reaction solution was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over sodium sulfate. The drying agent was removed and the target compound was obtained after concentration under reduced pressure (yellow oily substance, 4.45 g).

1. extractionThe reaction solution was extracted with ethyl acetate
2. washThe organic layer was washed with saturated brine
3. dry with materialdried over sodium sulfate
4. customThe drying agent was removed
5. customthe target compound was obtained
6. concentrationafter concentration under reduced pressure (yellow oily substance, 4.45 g)