Ammonia → 1-[2-Amino-6-(2-methylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

HRID 617975Notes

Reaction equation

HRID 617975 reaction equation
[C:1]1([CH3:19])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:17]([NH2:18])=[N:16][C:10]2[N:11]=[C:12]([NH2:15])[N:13]=[CH:14][C:9]=2[CH:8]=1.[C:20]([N:24]=[C:25]=[O:26])([CH3:23])([CH3:22])[CH3:21].N>C>[NH2:15][C:12]1[N:13]=[CH:14][C:9]2[CH:8]=[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=3[CH3:19])[C:17]([NH:18][C:25]([NH:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:26])=[N:16][C:10]=2[N:11]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 62412tert-Butyl isocyanateHCID 218500312,7-Diamino-6-o-tolyl-pyrido[2,3-d]pyrimidine

Product 1

HCID 53291181-[2-Amino-6-(2-methylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

Reagents, catalysts & solvents 1

HCID 297MethaneSolvent

Procedure

The title compound was prepared from 6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 90 and tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with CHCl3 :EtOAc (1:1) afford the pure product; mp 195-197° C., CIMS (1% ammonia in methane): m/z (relative intensity) 351 (MH+ +1, 55), 352 (MH+ +2, 12), 84 (100).

Workup

  1. customThe product was purified by MPLC
  2. washeluting with CHCl3 :EtOAc (1:1)
  3. customafford the pure product

Sources & evidence

ORD record
ord-2ff35ce2ad2f4dd39733ff6d3f17c3af
Source dataset
uspto-grants-1999_09
Patent number
US05952342

Reaction notes

Loading…