Isopropyl isocyanate → 6-Arylpyrido[2,3-d]pyrimidine deriv. 30

関与物質

反応手順

The procedure of Example 21 was followed to react 0.30 g of 7-amino-6-(2,6-dichlorophenyl)-2-(3-diethylamino-propylamino)-pyrido[2,3-d]pyrimidine from Example 20 and 0.077 mL of isopropyl isocyanate. The product was purified by medium pressure chromatography on silica gel eluting with 90:10:1 EtOAc:MeOH:TEA to afford the title compound, mp 88-100° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 504 (MH+, 3), 506 (MH+ +2, 2), 86 (100)

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