反应详情

3-Bromo-9-methoxy-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one (Compound JJ1, 1.50 g, 4.05 mmol) and pyridinium chloride (15.2 g, 32.5 eq.) were stirred at 160° C. for 12 hr under nitrogen atmosphere. After cooling, water and ethyl acetate were added and the resulting suspension was filtered. The organic layer was washed with water and saturated brine and dried over magnesium sulfate. After filtration and the concentration under reduced pressure, the resulting residues were washed with MTBE to obtain the title compound (brown solid, 1.47 g, 100%).

1. temperatureAfter cooling
2. filtrationthe resulting suspension was filtered
3. washThe organic layer was washed with water and saturated brine
4. dry with materialdried over magnesium sulfate
5. filtrationAfter filtration
6. concentrationthe concentration under reduced pressure
7. washthe resulting residues were washed with MTBE