2-Mercaptoethanol → 2-(2-Hydroxyethylthio)-3',4',5'-trimethoxyacetophenone

HRID 618082Notes

Reaction equation

HRID 618082 reaction equation
[SH:1][CH2:2][CH2:3][OH:4].Br[CH2:6][C:7]([C:9]1[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=1)=[O:8]>>[OH:4][CH2:3][CH2:2][S:1][CH2:6][C:7]([C:9]1[CH:10]=[C:11]([O:19][CH3:20])[C:12]([O:17][CH3:18])=[C:13]([O:15][CH3:16])[CH:14]=1)=[O:8]

Participants

3

Reactant 2

HCID 15672-MercaptoethanolHCID 36857322-Bromo-1-(3,4,5-trimethoxyphenyl)ethanone

Product 1

HCID 218501752-(2-Hydroxyethylthio)-3',4',5'-trimethoxyacetophenoneYield 76.9%

Procedure

Substantially the same procedure as in Reference Example 13 was repeated using 2-mercaptoethanol (0.82 g) and 2-bromo-3',4',5'-trimethoxyacetophenone (Compound XIa, 2.60 g) obtained in Reference Example 1 to give 2-(2-hydroxyethylthio)-3',4',5'-trimethoxyacetophenone (Compound IX-12, 1.98 g).

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-7795b3aedea84dec850e9e70695b0319
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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