4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one → HCID 21850252, compound

HRID 618097Notes

Reaction equation

HRID 618097 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1.Cl[CH2:27][C:28]1[O:29][C:30](=[O:34])[O:31][C:32]=1[CH3:33]>>[CH3:27][C:28]1[O:29][C:30](=[O:34])[O:31][C:32]=1[CH2:33][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1

Participants

3

Reactant 2

HCID 98555184-(Chloromethyl)-5-methyl-1,3-dioxol-2-oneHCID 9927763170488-48-9

Product 1

HCID 21850252HCID 21850252, compoundYield 6%

Procedure

Substantially the same procedure as in Example 3 was repeated using Compound 1 (2.37 g) obtained in Example 1 and 4-chloromethyl-5-methyl-1,3-dioxol-2-one (1.63 g) except that the obtained crude crystals were further purified by preparative high-pressure liquid chromatography (HPLC), to give Compound 11 (188 mg).

Workup

  1. customobtained crude crystals
  2. customwere further purified by preparative high-pressure liquid chromatography (HPLC)

Sources & evidence

ORD record
ord-fcbca8d85600470fa11cee97121fd54f
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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