3',4',5'-Trimethoxyacetophenone → HCID 21850275, compound

HRID 618111Notes

Reaction equation

HRID 618111 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:15])[CH3:14])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[Br:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][CH:21]=[C:20]2[CH:26]=O>>[Br:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][CH:21]=[C:20]2/[CH:26]=[CH:14]/[C:13]([C:5]1[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)=[O:15]

Participants

3

Reactant 2

HCID 143453',4',5'-TrimethoxyacetophenoneHCID 701375-Bromoindole-3-carbaldehyde

Product 1

HCID 21850275HCID 21850275, compoundYield 65.7%

Procedure

Substantially the same procedure as in Example 12 was repeated using 3',4',5'-trimethoxyacetophenone (2.1 g) and 5-bromoindole-3-carboxaldehyde (2.24 g) except that the obtained crystals were recrystallized from ethyl acetate, to give Compound 31 (2.73 g).

Workup

  1. customwere recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-b371f75ffa7147a7994d6b4d8df057e5
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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