Benzyl Bromide → HCID 21850202, compound

HRID 618118Notes

Reaction equation

HRID 618118 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1.[CH2:26](Br)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 9927763170488-48-9

Product 1

HCID 21850202HCID 21850202, compoundYield 70.3%

Procedure

Substantially the same procedure as in Example 3 was repeated using Compound 1 (2.37 g) obtained in Example 1 and benzyl bromide (1.8 g) except that the obtained crude crystals were recrystallized from ethanol and then from a mixed solvent of ethyl acetate and hexane, to give Compound 47 (2.11 g).

Workup

  1. customobtained crude crystals
  2. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-3e6f33faa13140b2949a0415a00d32b1
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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