HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Indole-3-Carboxaldehyde | HCID 10256 | — |
| Reactant | 2',5'-Dimethoxyacetophenone | HCID 70991 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one | HCID 54156913 | 44% |
Reaction Steps
2',5'-Dimethoxyacetophenone (1.80 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 72 hours. The precipitated crystals were collected by filtration, and the obtained crude crystals were recrystallized from ethanol to give Compound 89 (1.35 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952355 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-05fe39220067459285c6760684758e9b |
| Source note | uspto-grants-1999_09 |